50 days until NFL Kickoff, our experts already have a Bills vs. Rams best bet

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The NFL Preseason kicks off with the Hall of Fame Game on August 4, but we are officially 50 days away from the start of the NFL Regular Season! We already previewed the Buffalo Bills’ schedule earlier this summer, and we’ve outlined other key dates as we approach the upcoming season. We’ll explain when the preseason and regular season kick-off, in addition to the Week 1 schedule, which includes a best bet on the Buffalo Bills and Los Angeles Rams matchup. Let’s dive into what you can look forward to as we begin the 50 day countdown to the NFL Regular Season!

Betting Market	Best bet for NFL Week 1
Money line prediction	Buffalo Bills ML (-110)

When does the 2022 NFL Season begin?

The NFL regular season will kick off in exactly 50 days on Thursday, September 8 at 8:20 pm ET. The opening matchup will feature the Buffalo Bills against the Super Bowl champion Los Angeles Rams.

After Buffalo and Los Angeles get things started on Thursday night, the rest of the NFL will play across Sunday and Monday.

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NFL Regular Season Week 1 betting odds for every team

The Buffalo Bills and Los Angeles Rams are two teams that should give us plenty of entertainment in the season opener. However, 15 other NFL matchups should also be filled with excitement. Every Week 1 matchup with each team’s point spread odds provided by DraftKings Sportsbook can be seen here:

NFL Regular Season Week 1 matchups

• Buffalo Bills -1 (-105) vs. Los Angeles Rams +1 (-115)
• San Francisco 49ers -6.5 (-110) vs. Chicago Bears +6.5 (-110)
• Jacksonville Jaguars +4.5 (-110) vs. Washington Commanders -4.5 (-110)
• Pittsburgh Steelers +6.5 (-110) vs. Cincinnati Bengals -6.5 (-110)
• New Orleans Saints -4.5 (-110) vs. Atlanta Falcons +4.5 (-110)
• Cleveland Browns -1 (+100) vs. Carolina Panthers +1 (-120)
• Baltimore Ravens -6 (-105) vs. New York Jets +6 (-115)
• Philadelphia Eagles -4 (-110) vs. Detroit Lions +4 (-110)
• New England Patriots +2.5 (+100) vs. Miami Dolphins -2.5 (-120)
• Indianapolis Colts -8 (-110) vs. Houston Texans +8 (-110)
• New York Giants +6.5 (-110) vs. Tennessee Titans -6.5 (-110)
• Green Bay Packers -2 (-110) vs. Minnesota Vikings +2 (-110)
• Las Vegas Raiders +3.5 (-115) vs. Los Angeles Chargers -3.5 (-105)
• Kansas City Chiefs -3 (-110) vs. Arizona Cardinals +3 (-110)
• Tampa Bay Buccaneers -2 (-110) vs. Dallas Cowboys +2 (-110)
• Denver Broncos -4.5 (-110) vs. Seattle Seahawks +4.5 (-110)

Our experts analyzed the season opener between the Buffalo Bills and Los Angeles Rams and have one best bet for the matchup.

RELATED: Buffalo Bills schedule and win total prediction: Odds at FanDuel favor the Bills in the 2022 NFL season

NFL Regular Season Week 1 Buffalo Bills vs. Los Angeles Rams money line prediction: Bills ML (-110)

The Buffalo Bills take on the defending Super Bowl Champions in the NFL regular season opener, and we think they can defeat the Los Angeles Rams. The NFL is a quarterback-driven league, and Buffalo’s Josh Allen is one of the best. We talked about him being the favorite to win this year’s MVP, and he is still leading the pack with +700 odds at FanDuel Sportsbook. Allen will be hungry to grab a win after the Bills’ disappointing exit in last year’s playoffs, and Buffalo added multiple key players in free agency and the NFL Draft to improve their squad.

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Running back James Cook and cornerback Kaiir Elam were the Bills’ first two selections in the 2022 NFL Draft, and both players should make an impact at some point this season. The two rookies could see snaps in Week 1, and it will be worth monitoring how All-Pro CB Tre’Davious White looks in the preseason after suffering an ACL tear last season. Both selections were strong, but the biggest name Buffalo added in the offseason is former Rams linebacker, Von Miller. Miller will likely enjoy the company of his former team leading up to kickoff, and we expect him to be a major asset for Buffalo’s pass rush.

The Rams added a few significant players this offseason, but they could have a slight hangover from last year’s Super Bowl win. Additionally, the Bills lost last season’s opener as 7-point favorites to the Pittsburgh Steelers, and head coach Sean McDermott knows they cannot come out slow again. Therefore, we’ll back the Bills to grab a win in Week 1. Make sure you check out our season preview if you want more analysis around Buffalo’s 2022 outlook.

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READ MORE ABOUT THE BILLS

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TALK ABOUT THE BILLS

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